Mass spectrometry based proteomics, background, status and future needs
نویسندگان
چکیده
منابع مشابه
Computational Mass Spectrometry–Based Proteomics
Proteomics is defined as the system-wide characterization of all the proteins in an organism in terms of their sequence, localization, abundance, post-translational modifications, and biomolecular interactions. Modern proteomic investigations are increasingly quantitative and comprehensive [1]. Examples include the relative quantification of over 4,000 proteins in haploid and diploid yeast, whi...
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In the life sciences, a new paradigm is emerging that places networks of interacting molecules between genotype and phenotype. These networks are dynamically modulated by a multitude of factors, and the properties emerging from the network as a whole determine observable phenotypes. This paradigm is usually referred to as systems biology, network biology, or integrative biology. Mass spectromet...
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THE 15TH ASILOMAR CONFERENCE on Mass Spectrometry this October was devoted to the role of mass spectrometry (MS) in proteomics. The Asilomar Conference site is in a picturesque national park in Pacific Grove, CA, overlooking the Pacific Ocean. The conference aims to bring together scientists from a cross section of disciplines that are applying MS to an emerging field. This year, that emerging ...
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proteomics concerns itself with the characterization and function of all cellular proteins, the ultimate determinants of cellular function. mass spectrometry has emerged as the preferred method for in-depth characterization of the protein components of biological systems. using mass spectrometry, key insights into the composition, regulation and function of molecular complexes and pathways have...
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In recent years, mass spectrometry has moved more than ever before into the front line of protein-centered research. After being established at the qualitative level, the more challenging question of quantification of proteins and peptides using mass spectrometry has become a focus for further development. In this chapter, we discuss and review the strategies and problems of the methods current...
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ژورنال
عنوان ژورنال: Protein & Cell
سال: 2012
ISSN: 1674-800X,1674-8018
DOI: 10.1007/s13238-012-2079-5